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Michelle Cherne

Assistant Professor | College of Engineering and Science: Biomedical Engineering and Science

Contact Information

Expertise

Organoids, extracellular matrix, gastrointestinal tract, infectious disease, mucosal immunology, microphysiological systems

Educational Background

Ph.D., Biomedical Sciences, University of Central Florida, 2020

B.S., Biotechnology, University of Central Florida, 2016

Professional Experience

Assistant Professor, Florida Institute of Technology, 2025

Research Scientist, Montana State University, 2024-2025

Post Doctoral Researcher, Montana State University, 2020-2024

Current Courses

BIO 4010 - Biochemistry 1

 

Selected Publications

Cherne, MD, Sidar B, Sebrell, TA, Sanchez HS, Heaton, K, Kassama FJ, Roe MM, Gentry AD, Chang CB, Walk ST, Jutila M, Wilking JN, Bimczok D, A Synthetic Hydrogel, VitroGel® ORGANOID-3, Improves Immune Cell-Epithelial Interactions in a Tissue Chip Co-Culture Model of Human Gastric Organoids and Dendritic Cells. Front Pharmacol,12: p. 707891. 2021.

Mahdieh Z, Cherne MD, Fredrikson JP, Sidar B, Sanchez HS, Chang CB, Bimczok D, Wilking JN, Granular Matrigel: Restructuring a Trusted Extracellular Matrix Material for Improved Permeability. Mater., 2022.

Cherne MD, Gentry AB, Nemudraia A, Artem Nemudryy A, Hedges JF, Walk H, Blackwell K, Snyder DT, Jerome M, Madden W, Hashimi M, Sebrell TA, King DB, Plowright RK, Jutila MA, Wiedenheft B, Bimczok D, SARS-CoV-2 detected in the gastrointestinal tract of asymptomatic endoscopy patients poses minimal transmission risk. Gastro. Hep. Advances, 2022

Research

Dr. Cherne's research focuses on how the extracellular matrix shapes mucosal host response, particularly to the oncogenic pathogen, Helicobacter pylori. Dr. Cherne investigates the interactions of the extracellular matrix with epithelial, stromal, and immune cells of the gastrointestinal tract. To support this work, her lab develops human-derived extracellular matrix hydrogels and microphysiological systems to model the human gastrointestinal mucosa. 

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